Methods like Auto-Tune and/or sample replacement aren’t as effective on acoustic guitar as they are when used in other contexts, I find equalization to be a nearly indispensable tool when mixing acoustic guitar.
I’ve mixed plenty of tracks in which the acoustic guitar is intended to be in a place of sonic prominence. In these cases, I’ll try to preserve as much of the frequency spectrum as possible. Alternately, if it’s meant to be a subtle flavor used sparingly, I’ll apply a liberal amount of subtractive EQ or filtering to allow the other elements to command the listener’s attention.
Read more about this here: https://theproaudiofiles.com/eq-acoustic-guitar/